Letter to Physicians: Four New Scientific Discoveries Regarding the Safety and Efficacy of COVID-19 Vaccines

By Doctors for COVID Ethics


Doctors for Covid Ethics has sent the following letter to tens of thousands of doctors in Europe, summarising four recent scientific findings critical to the COVID-19 vaccination program. The letter explains each finding as it relates to the biology of COVID-19 vaccines, including interactions with the immune system.

Taken together, the letter warns that these new pieces of evidence force all physicians administering COVID-19 vaccines to re-evaluate the merits of COVID-19 vaccination, in the interests of their own ethical standing, and their patients’ safety and health.

A video explanation of the underlying immunology by Professor Sucharit Bhakdi MD is here, with German subtitles here.


Dear Colleague:

Four recent scientific discoveries are herewith brought to your urgent attention. They alter the entire landscape of the COVID-19 pandemic, and they force us to reassess the merits of vaccination against SARS-CoV-2.


Rapid and efficient memory-type immune responses occur reliably in virtually all unvaccinated individuals who are exposed to SARS-CoV-2. The effectiveness of further boosting the immune response through vaccination is therefore highly doubtful. Vaccination may instead aggravate disease through antibody-dependent enhancement (ADE).

Discovery 1: SARS-CoV-2 spike protein circulates shortly after vaccination

SARS-CoV-2 proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of Moderna mRNA-1273 vaccine [1]. With 11 of the 13, the SARS-CoV-2 spike protein was detected in the blood within only one day after the first vaccine injection.

Significance. Spike protein molecules were produced within cells that are in contact with the bloodstream—mostly endothelial cells—and released into the circulation. This means that a) the immune system will attack those endothelial cells, and b) the circulating spike protein molecules will activate thrombocytes. Both effects will promote blood clotting. This explains the many clotting-related adverse events—stroke, heart attack, venous thrombosis—that are being reported after vaccination.

Discovery 2: Rapid, memory-type antibody response after vaccination

Several studies have demonstrated that circulating SARS-CoV-2-specific IgG and IgA antibodies became detectable within 1-2 weeks after application of mRNA vaccines [1–3].

Significance. Rapid production of IgG and IgA always indicates a secondary, memory-type response that is elicited through re-stimulation of pre-existing immune cells. Primary immune responses to novel antigens take longer to evolve and initially produce IgM antibodies, which is then followed by the isotype switch to IgG and IgA.

A certain amount of IgM was indeed detected alongside IgG and IgA in some studies [1,4]. Importantly, however, IgG rose faster than IgM [4], which confirms that the early IgG response was indeed of the memory type. This memory response indicates pre-existing, cross-reactive immunity due to previous infection with ordinary respiratory human coronavirus strains. The delayed IgM response most likely represents a primary response to novel epitopes which are specific to SARS-CoV-2.

Memory-type responses have also been documented with respect to T-cell-mediated immunity [5–7]. Overall, these findings indicate that our immune system efficiently recognizes SARS-CoV-2 as “known” even on first contact. Severe cases of the disease thus cannot be ascribed to lacking immunity. Instead, severe cases might very well be caused or aggravated by pre-existing immunity through antibody-dependent enhancement (ADE, see below).

Discovery 3: SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity

Serum antibody profiles were reported for 203 individuals following SARS-CoV-2 infection [8]. 202 (>99%) of the participants exhibited SARS-CoV-2 specific antibodies. With 193 individuals (95%), these antibodies prevented SARS-CoV-2 infection in cell culture and also inhibited binding of the spike protein to the ACE2 receptor. Furthermore, CD8+ T-cell responses specific for SARS-CoV-2 were clear and quantifiable in 95 of 106 (90%) HLA-A2-positive individuals.

Significance. This study confirms the above assertion that the immune response to initial contact with SARS-CoV-2 is of the memory type. In addition, it shows that this reaction occurs with almost all individuals, and particularly also with those who experience no manifest clinical symptoms.

The goal of the vaccination is to stimulate production of antibodies to SARS-CoV-2, but we now know that such antibodies can and will be rapidly generated by everyone upon the slightest viral challenge, even without vaccination.

Severe lung infections always take many days to develop, which means that if the antibodies generated by the memory response are needed, they will arrive on time. Therefore, vaccination is unlikely to provide significant benefit with respect to the prevention of severe lung infection.

Discovery 4: Rapid increase of spike protein antibodies after the second injection of mRNA vaccines

IgG and IgA antibody titres were monitored before vaccination and after the first and the second injection of mRNA vaccines [3]. Antibody titres rose with some delay after the first injection, then plateaued, but rose again very shortly after the second injection.

Significance. Even though the antibody response to the first injection is of the memory type, the small time lag after the injection may mitigate adverse reactions, because the abundance of spike protein on the cells in the blood vessel walls and in other tissues may have already passed its peak when the antibodies arrive.

The situation changes dramatically with the second injection. Then the spikes are produced and protrude into the bloodstream that is already swarming with both reactive lymphocytes and antibodies. The antibodies will cause the complement system [9,10] and also neutrophil granulocytes to attack the spike protein-bearing cells. The possible consequences of all-out self-attack by the immune system are frightening.

Antibody-dependent enhancement of disease

As described, memory-type immune responses ensure the rapid rise of antibody titres after initial exposure to SARS-CoV-2, rendering the benefit of vaccine-induced antibody response exceedingly doubtful. Regardless, we should not assume that high antibody titres against SARS-CoV-2 will always improve the clinical outcome. With several virus families—in particular with Dengue virus, but also with coronaviruses—antibodies can aggravate rather than mitigate disease. This occurs because certain cells of the immune system take up antibody-tagged microbes and destroy them. If a virus particle to which antibodies have bound is taken up by such a cell, but it then manages to evade destruction, it may instead start to multiply within the cell. Overall, the antibody will then have enhanced the replication of the virus. Clinically, this antibody-dependent enhancement (ADE) can cause a hyperinflammatory response (a “cytokine storm”) that will amplify the damage to the lungs, liver and other organs of our body.

Attempts to develop vaccines to the original SARS virus, which is closely related to SARS-CoV-2, repeatedly failed due to ADE. The vaccines did induce antibodies, but when the vaccinated animals were subsequently infected with the virus, they became more ill than the unvaccinated controls (see e.g. [11]). The possibility of ADE was not adequately addressed in the clinical trials on any of the COVID-19 vaccines. It is therefore prudent to avoid the danger of inducing ADE through vaccination and instead rely on proven forms of treatment [12] for dealing with clinically severe COVID-19 disease.


The collective findings discussed above clearly show that the benefits of vaccination are highly doubtful. In contrast, the harm the vaccines do is very well substantiated, with more than 15.000 vaccination-associated deaths now documented in the EU drug adverse events database (EudraVigilance), and over 7.000 more deaths within the UK and the US [13].



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1. Ogata, A.F. et al. (2021) Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients. Clin. Infect. Dis. -:x-x

2. Amanat, F. et al. (2021) SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD and S2. Cell -:x-x

3. Wisnewski, A.V. et al. (2021) Human IgG and IgA responses to COVID-19 mRNA vaccines. PLoS One 16:e0249499

4. Qu, J. et al. (2020) Profile of Immunoglobulin G and IgM Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin. Infect. Dis. 71:2255-2258

5. Le Bert, N. et al. (2020) SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls. Nature 584:457-462

6. Grifoni, A. et al. (2020) Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals. Cell 181:1489-1501.e15

7. Gallais, F. et al. (2021) Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion. Emerg. Infect. Dis. 27:x-x

8. Nielsen, S.S. et al. (2021) SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity. EBioMedicine 68:103410

9. Magro, C.M. et al. (2020) Docked severe acute respiratory syndrome coronavirus 2 proteins within the cutaneous and subcutaneous microvasculature and their role in the pathogenesis of severe coronavirus disease 2019. Hum. Pathol. 106:106-116

10. Magro, C.M. et al. (2021) Severe COVID-19: A multifaceted viral vasculopathy syndrome. Annals of diagnostic pathology 50:151645

11. Tseng, C. et al. (2012) Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus. PLoS One 7:e35421

12. McCullough, P.A. et al. (2021) Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection. Am. J. Med. 134:16-22

13. Johnson, L. (2021) Official Vaccine Injury and Fatality Data: EU, UK and US.

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32 thoughts on “Letter to Physicians: Four New Scientific Discoveries Regarding the Safety and Efficacy of COVID-19 Vaccines”

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    1. This video is testimony that people need help.

      Many other concerned websites prove that human beings have learned little to nothing about how do deal with pandemics since around the year 1500. This is when people began to record the efforts to deal with pandemics, etc.

      The first official reaction is to go into PANIC mode and continue on that track until exhaustion or death occurs.

      There are a few every-day people who are calm and collected but they’re drowned out by the nattering nabobs of negativism.

  5. For the record, this is the ‘spike’ in reported ‘coronavirus cases’ that led Los Angeles County to reinstate the indoor mask mandate. It was a recommendation made by a nervous governor under recall, to all California counties which, except for us, wisely demurred.


    1. This regressive mandate is such a shame because masks were being abandoned with alacrity all around Los Angeles. Trader Joe’s of all woke places had dropped them. There is some doubt as to whether this trend can be rolled back as people are so ready to move on. We will see how successful the government will be in re-instituting their repressive measures.

    2. The ‘covid’ numbers have always been fake; why the underwhelming manipulation this time in Los Angeles? I want to believe that they couldn’t get it rolling because the masses are tired of it, but everyone seems to be going along with the reinstated mandate.

  6. The CDC have OK’d the bioweapon pretending to be a vaccine for 12 year olds. At the very least this will cause heart inflammation, sterilization, block puberty and destroy a generation. This alone shows the CDC to be a criminally dangerous organization that should be stripped of funding and power.
    There should be arrests and prosecutions.

    1. In spite of all the evidence we have regarding the dangers of a toxic “vaccination” for an unproven virus that has had no significant mortality rate compared to the past 20 years, your comment and mine are what the government are seeking to label misinformation and be banned from social media according to “Sacky” the mouth piece for controllers.

      >>There should be arrests and prosecutions.>>

      Indeed…far too many victim episodes to list here from JFK, 9/11, and Sandy Hook to Seth Rich, Vince Foster, and the DC Madam. With this false flag “pandemic” they are now sticking it in our faces.

      The biggest ? now is will people rise above their psychological conditoning and rise up??
      – – – – – – – – – – – – –
      “The individual is handicapped by coming face to face with a conspiracy so monstrous he cannot believe it exists.”
      – J. Edgar Hoover

      GOTTA RISE UP https://www.bitchute.com/video/Uh1qi1mhC3sG/

      1. “The individual is handicapped by coming face to face with a conspiracy so monstrous he cannot believe it exists.”
        – J. Edgar Hoover

        Of course, Hoover’s cross-dressing would not come under that category.

    1. AZ, thanks, excellent video. The guy must have been a good Marshall back in the day.

      So it is:
      Don’t answer the door.
      If you do, don’t talk to them.
      If they persist, inform them they are on private property.
      Still persist, give the 60 secons b4 you call 911.

    2. >>Of course, Hoover’s cross-dressing would not come under that category.>>


      I have finally figured out that “replies” don’t get the red buttons so I just find one of your comments and do it that way. No reply yet from Jim regarding what it would take to program an upvote tick box to make it easy to agree or if he would even want one.

      I was pruning trees and burning this and that this week. Today I got my Honda gen out of my van to give it regular start up between my hacking and hewing, tore something in my right shoulder trying to start it :-/ can barely type now.
      Why when I was a whipper snapper I could….. 🙂

      1. Ah yes, the days of whippersnappperdom; when ibuprofen was a medicine and not a condiment. I remember them well.

    1. The edited video does not complete in that did he correct himself? If true, then where are the bodies and outrage? Much like the lie last year about “millions” dying in China from CV-19.

      1. EJD, I have looked at this video multiple times and slowed it down to watch his lips. I can see no discrepancy. Someone with better skills than myself is welcome to examine it. If real, it seems to be a Freudian slip. Subsequent versions and even transcripts appear to have have changed the word vaccination to virus. Check it out yourself. It is possible this video was altered. I don’t know. It’s very interesting those who have commented (Tucker, Ingraham) have not mentioned the slip. Here is an obviously altered version of the speech. Watch carefully. You will see the gap.


    2. No reply box INRE: The video. (note: Jim, is there anyway possible to put an upvote box here. It would save you much time, plus it is quick communication, letting the person know they have been “heard.”)

      When I said “edited” I was referring to the presented version, repeating, etc. and not any manipulation of his speech. Thanks for the effort, since WE know that millions didn’t die of either the pretend virus nor the toxic injection his comment is really moot.

      Yeah, that 16 min vid is well edited, prob by the people who were presenting it?? Durban is trying to show their is some division amongst the Fox crews. Couldn’t convince me of anything using that loud mouth, can’t shut up and let a guest speak, narcissistic twit Sean Hannity.

      Fox made itself very clear when the fired Lou Dobbs. Why Maria, Tucker, and Laura are still on is mystery. For $$ ratings perhaps?

  7. The US has been in extreme decline since the daylight bloody murder of JFK… that was NEVER fully investigated.
    Many people say that the US is a 3rd world country. No its not, its in a special category that is beneath 3rd world.

    Its a lawless depraved country that allows fraud and fakery on a cosmic scale. Any nation that would allow events like Sandy Hook Hoax to terrify millions of people is in fatal decline. The DOJ even permits books about Sandy Hook to be hidden and banned from public view.

    Several people are annoyed by my photos but here is another one. Yeah, I know, you’ve seen it before but SH is a malignant cancer that persists. Cancers can persist until the victim is dead.


    1. Jussie Smollett was back in the news this week due to more legal trouble stemming from his hate-crime hoax. Sandy Hook is no more real than the Jussie Smollett attack. Except, Sandy Hoax has the deep state, the courts and the media pushing the lie.

  8. Much of the article is above my level of understanding but my gut sense from the outset is stated in the conclusion. Mainly that any benefits from the vaccine are highly doubtful. I felt in the initial trials they could test for safety, but not for the effectiveness in preventing disease. Given what is being reported in the article, any claims that the vaccine is safe and effective, appear to be highly dubious.
    The promise of the vaccine seems very similar to the WMD’s in Iraq that were never found. Fraudulent elections are more concerning to me than the virus. The US with the help of a derelict Supreme Court has installed an illegitimately elected person who shows extreme cognitive decline day after day, while pushing an agenda that is extremely bad for the citizens of the country.

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